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One potential argument that APAP cannot cause ASD is that the rising rates of ASD over time are, at least in part, a consequence of changing diagnostic criteria, increased awareness, and other factors (discussed by co-author CDN and colleagues [35])

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These changes are also related to improvements in quality of life, as they can alleviate common symptoms such as fatigue, jaundice, and gastrointestinal discomfort in patients with advanced liver disease [44]