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The decline in estrogen slows metabolism, increases fat storage (particularly in the belly), and makes it harder to maintain muscle mass

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It may mean the pace of escalation is too aggressive, the patients nutrition is not keeping up, or constipation and hydration need to be addressed first

Key Facts: Full Name : Glucose-dependent insulinotropic polypeptide Also Known As : Gastric inhibitory polypeptide (older term, now less favored) Produced By : K-cells in the proximal small intestine Stimulus for Release : Nutrient ingestion, especially glucose and fat Main Actions : Stimulates insulin secretion (only when glucose is elevated) Influences fat metabolism Modulates energy balance and satiety May impact bone turnover and neuroprotection Where Is GIP Produced