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This compromises the integrity of the lungs, making them more susceptible to infection and inflammation (64)

In animal models of psychosis, liraglutide administration consistently led to a reduction of psychotic-like behavior 119,120,121 , which was also associated with increased brain-derived neurotrophic factor, CREB/p-CREB, and Trk-B expression in the hippocampus and prefrontal cortex 120 , and reduced serum and hippocampal tumor necrosis factor and oxidative stress 121

Although our findings may support the use of GLP-1 RAs as first-line type 2 diabetes treatment for the prevention of DR, further research such as a randomized clinical trial study with a longer follow-up time is warranted to establish more robust evidence

The final reaction volume was 100 l