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Or, the glutamate can be further converted to GABA using the GAD1 enzyme, which requires the active form of vitamin B6 (P5P) as a cofactor.[ref] Genetic variants that reduce the conversion of B6 to its active form, P5P, could therefore impact GABA synthesis and GABAergic neurons

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B12 injections help correct deficiencies and support metabolism, but they must be paired with proper nutrition, caloric strategy, movement, and accountability