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IGF-1 is one of the primary activating signals for satellite cells, and understanding how sustained IGF1R activation affects satellite cell proliferation, differentiation, and fusion is a key question in muscle biology

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Interestingly, in people with type 2 diabetes mellitus, who often exhibit glomerular hyperfiltration, GLP-1 receptor agonists stabilize or modestly reduce eGFR, an effect reminiscent of the initial declines observed with RAAS and SGLT2 inhibitors [64]