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Given that the half-life of SGLT2 inhibitors varies from 11 to 13 hours, it seems reasonable to withhold these medications for three days (or five half-lives) before elective surgery

Semaglutide is currently the most prominent approved option in this class: Ozempic (semaglutide injection) licensed for type 2 diabetes management Wegovy (semaglutide 2.4 mg injection) licensed specifically for chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity

Possible side effects GLP-1 receptor agonists can cause side effects such as nausea, vomiting, diarrhea, constipation, and abdominal pain

"The triple-agonist design of Retatrutide offers an unprecedented mechanism of action, targeting multiple synergetic metabolic pathways to optimize energetic homeostasis in laboratory models." Preclinical in-vitro models indicate that GIP and GLP-1 receptor activations synergistically stimulate glucose-dependent insulin secretion, while glucagon receptor activation increases cellular energy expenditure and fatty acid oxidation