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8.5 Extension to dual, triple-agonist and amylin-based co-agonist therapies The emergence of dual and multi-agonist therapies, such as the GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist tirzepatide, raises important questions regarding the generalisability of the proposed framework

Bydureon BCise (exenatide extended-release) Bydureon BCise is a GLP-1 agonist with the active ingredient extended-release exenatide

Other brain regions with GLP-1 receptor expression include: Ventral tegmental area and nucleus accumbens (reward and motivation circuits) Amygdala (emotional processing and stress responses) Prefrontal cortex (executive function and decision-making) Substantia nigra (motor control, relevant to Parkinson's disease research) This widespread distribution suggests that GLP-1 influences diverse neurological functions beyond appetite regulation

MEDVi structures treatment plans with periodic reviews to ensure safety and effectiveness