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Studies suggest that As induces the generation of Reactive Oxygen Species (ROS) leading to oxidative stress and lipid peroxidation in plants (Shukla et al., 2018)

In a rat model of MCAO-induced stroke, neurogenesis was increased by semaglutide treatment, as evidenced by significantly increased levels of neurogenesis-specific biomarkers including nestin (intermediate filament protein that is a known marker of neuronal progenitor cells), doublecortin (microtubule-associated protein considered to be a reliable marker of neurogenesis), stromal cell-derived factor-1 (SDF-1) (chemokine promoting endogenous regeneration in the ischemic brain), and its receptor CXCR4

To complement the functionality tolerated on the (hetero)aryl ring, we sought to derivatize the bridgehead to generate a library of the underrepresented -naphthyl isostere building blocks (Fig

That prevents coordination with the program and can slow verification of support, bridging, or coverage details