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Tirzepatide and similar GLP-1 receptor agonists work by activating appetite-suppressing pathways in the hypothalamus and brainstem, causing many patients to experience reduced cravings for sweets within the first 24 weeks of treatment

Acknowledgements This work is supported by National Nature Foundation of China (81371988), Zhejiang Provincial Health Department Foundation of China (2016KYB196 and LY15H060008)

Extended-release formulations are usually taken once daily with dinner

"All of these things go together, and our goal is not only to make people smaller but also to make people healthier and stronger, which is so powerful." As more people explore the use of GLP-1 medicines -- KFF said about a third of adults had heard a lot about the drugs -- it will be integral for providers to practice holistic patient engagement and chronic disease management with their patients