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The search strategy combines Medical Subject Headings (MeSH) and keywords including GLP-1, glucagon-like peptide-1 receptor, GLP-1 receptor agonist, sepsis, systemic inflammation, infection, immune response, critical illness, MODS, multiple organ dysfunction, cytokines and sepsis treatment. Articles were screened for relevance based on titles and abstracts, with full-text evaluation of studies addressing the mechanistic or therapeutic implications of GLP-1 signaling in experimental or clinical models of sepsis

In addition, lower levels of tumor necrosis factor- (TNF-) and CGRP in the serum of patients enrolled in the CoQ10-arm, suggest that these effects are through the reduction of inflammatory processes (163)

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