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When the first GLP-1 RA, exenatide, was released in 2005, the sole indication was for glycemic control, and weight loss was deemed a favorable side effect

Genetic predisposition does not predict exact medication response but can inform a more nuanced provider discussion about dose optimization or alternative compounds

Focus on: High-protein foods (lean meat, fish, eggs, legumes, Greek yoghurt) at each meal to enhance satiety High-fibre vegetables and whole grains to slow digestion and prolong fullness Adequate hydration (6-8 glasses of fluid daily, approximately 1.2 litres, more during hot weather or exercise), as thirst is often mistaken for hunger Regular meal timing (three balanced meals with planned snacks if needed) to stabilise blood glucose and prevent extreme hunger Minimising ultra-processed foods and refined sugars that cause rapid blood glucose fluctuations Addressing lifestyle factors can significantly improve appetite regulation

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