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Regarding gastrointestinal tolerability, 83% of treated participants reported no or only mild key gastrointestinal adverse events

Through the above mechanisms, GLP-1RAs can mediate the function of regulating endothelial-mediated contraction and vasodilation, as well as maintaining the stability of the endothelial barrier

This contributes to stress on the nervous system (pain), cartilage erosion and subchondral bone defects and instability of the ligaments and tendons further perpetuating the mechanical stress induced fibrotic synovitis

This approach can help sensitive individuals titrate more gradually, reducing the shock of jumping from one full dose level to the next