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Further, a study provided evidence that long-time cigarette smoking leads to increased testosterone metabolism in the liver, concurrently causing secretory dysfunction of Leydig and Sertoli cells (80)

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3.2 Miscellaneous sources There are many exogenous sources of ROS generation, for examples, transition metal ions likely iron (Fe), zinc (Zn) and copper (Cu) have the abilities to induce oxidative stress in living cells via performing Fenton and Haber-Weiss reactions

Furthermore, we highlight limitations of the current research on utility of AOXs for treatment of infertile couples and the need for well-designed studies that can bridge the gap between research and practice in this regard