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This is the same physiologic process seen when someone stops lifting weights: muscle size decreases because the stimulus is gonenot because muscle is being destroyed. Common Misconception: GLP-1 Drugs Burn Muscle Reality: Muscle loss during GLP-1associated weight loss is driven by reduced mechanical load and insufficient protein/calories , not by a toxic or catabolic drug effect. When Lean-Mass Loss Becomes True Muscle Wasting True muscle wasting is uncommon with GLP-1 therapy and is usually related to undernutrition , not the medication itself

Clinical trial results discussed in this article - STEP 1 (14.9% average body weight loss with semaglutide), SURMOUNT-1 (20.9% average body weight loss with tirzepatide), and SELECT (20% reduced risk of major cardiovascular events with FDA-approved Wegovy in a specific patient population) - relate to studied active ingredients and specific FDA-approved formulations in controlled trial populations and should not be interpreted as guaranteed outcomes for any individual patient or compounded formulation

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