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Animals (n=6/each group) were categorized into group 1 (sham-control of F344 rat), group 2 (sham-control of DPP4-deficiency rat), group 3 [AHS by right cerebral injection of autologous blood (100 L) in F344 rat], group 4 (AHS + sitagliptin/600 mg/kg 3 h prior to and at 3 h then once per day after AHS) and group 5 (AHS in DPP4-deficiency rat)

Vutiglabridin, through its direct fat-reducing mechanism, helps overcome this limitation and supports sustained weight loss until normal body weight is reached

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these findings may explain in part the limited nature of the metabolic improvements observed in response to pharmacologic intervention 2,10