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Additionally, sitagliptin has been shown to lower the proinsulin-to-insulin ratio (an indicator of -cell function) and increase the homeostasis model assessment-B index, a measure of insulin production (49, 50)

and change in physical function, evaluated via the 36-item Short Form Health Survey (SF-36)

In women, elevated prolactin levels are thought to cause infertility by suppressing pulsatile gonadotropin releasing hormone (GnRH) release that is necessary to induce luteinizing hormone (LH) and follicle stimulating hormone (FSH) secretion and ovulation (41)

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