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10.3390/pharmaceutics16040505 26

Ann Intern Med 2003

Current medications provide symptom relief rather than exerting disease-modifying effect

The increase of ROS and TMAO-derived oxidative stress-related molecule malondialdehyde (MDA) impaired the activity of endothelial nitric oxide synthase (eNOS), contributing to decreased nitric oxide (NO) bioavailability and endothelial dysfunction in aged rats (76, 77)