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In STEP 1, participants without diabetes who received semaglutide 2.4 mg weekly lost an average of 14.9% of their body weight over 68 weeks compared to 2.4% with placebo

After activation, TLR4 recruits two adaptor proteins (MyD88 and TRIF) to activate downstream kinases (TAK1, MAPKs, TBK1, and IRF3) and transcriptional factors such as NF-B, AP-1, and IRF, respectively, inducing inflammatory gene transcription and cytokine expression 13

Wegovy injection was first approved in June 2021 and the oral pill was approved in December 2025