how does tirzepatide help pcos helps with and insulin resistance ObesityWeek: Tirzepatide Helps Shed Weight

Source: Jastreboff et al., NEJM 2023 TRIUMPH-4 Phase 3 (68 weeks, 445 participants) Phase 2 Type 2 Diabetes Trial (36 weeks, 281 participants) In the type 2 diabetes population, weight loss was lower than in the obesity trial which is consistent with the pattern seen across all GLP-1 drugs

N.KnappE.et al (2021)

These findings support their role as a cornerstone therapy in the management of heart failure across the entire clinical spectrum ( Table 1 )

The GLP-1 era is therefore accelerating portfolio discipline decisions that many companies were already overdue to make, which means the question is not really whether to rationalize but whether to do it on the companys own terms or under duress