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A primary mechanism is the disruption of the epithelial barrier via its virulence adhesin FadA, which binds to E-cadherin on host cells, leading to the activation of the NF-B pathway and the upregulation of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6 (Li et al., 2021

Mol Biol Rep (2021) 48(1):5766

Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex