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BPC-157 has been found to modulate the stress response by regulating the release of stress hormones, such as corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH)

The breadth of DSIPs biological activity spanning sleep regulation, stress modulation, pain processing, antioxidant defence, and neuroprotection has led some researchers to characterise it as an adaptogenic peptide: one that supports homeostatic balance across multiple physiological systems rather than acting on a single discrete target

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