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Author contributions HG: Validation, Data curation, Methodology, Writing original draft, Investigation, Funding acquisition

These studies provide abundant evidence for its safety at doses far exceeding what any human encounters in the diet

In the phase 1/2 trial, alpelisib (a PI3K inhibitor) plus nab-paclitaxel was well tolerated and showed encouraging efficacy, especially in patients with metastatic PIK3CA -mutated HER2 breast cancer, despite that TNBC has lower efficacy than HR+/HER2 patients

CONCLUSIONS This study provides epidemiological evidence of associations of smoking with serum uric acid levels, hyperuricemia, and gout in women but not in men