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In women with PCOS, high concentrations of leptin have been reported to inhibit the expression of aromatase mRNA in granulosa cells, while the hyperandrogenic follicular environment in GCs was found to significantly reduce the expression of P450arom, which can convert androgens into estrogen, further increasing the levels of androgens and ultimately promoting follicular atresia (148150)
doi: 10.2147/PPA.S277676
Intensive glycemic control and macrovascular, microvascular, hypoglycemia complications and mortality in older (age 60years) or frail adults with type 2 diabetes: a systematic review and meta-analysis from randomized controlled trial and observation studies
DSMES should be person-centered and can be provided in group or individual settings, involving the entire diabetes care team
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