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Specific NAD and glutathione forms correlate with glucose and lipid homeostasis and liver function The result that the redox metabolites follow a gaussian distribution in normal population, together with the previous knowledge that niacin supplementation can increase blood glucose and decrease cholesterol levels 28 prompted us to ask whether physiological NADs and glutathione levels correlated with glucose and lipid homeostasis, liver function tests, B vitamins and fatty acid metabolism in healthy individuals (Fig

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Only the antihyperglycemic effect of these drugs appears to be clearly related to the potentiation of incretins (i.e., GLP-1 and glucose-dependent insulinotropic polypeptide) [102, 103], possibly because such potentiation is confined to the gastrointestinal tract and may not be manifest systemically [63]