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Stay at the lowest effective dose if 1mg achieves clinical targets, there is no cost reason to titrate to 2mg

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In 2025, nearly three-quarters (72%) face an out-of-pocket maximum of more than $3,000 for single coverage, including one in five (21%) who face an out-of-pocket maximum of more than $6,000

Variants in genes like PER2 (circadian rhythm) and COMT (stress metabolism) can affect how sensitive you are to semaglutide's systemic effects