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Review Article Open access Published: 18 September 2024 Glucagon-like peptide-1 receptor: mechanisms and advances in therapy Signal Transduction and Targeted Therapy volume 9 , Article number: 234 (2024) Cite this article Abstract The glucagon-like peptide-1 (GLP-1) receptor, known as GLP-1R, is a vital component of the G protein-coupled receptor (GPCR) family and is found primarily on the surfaces of various cell types within the human body