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Call 911 or seek emergency care immediately if cold sensitivity develops suddenly or worsens dramatically, particularly if accompanied by other new symptoms such as severe chest pain, shortness of breath, irregular heartbeat, or changes in mental status

Conversely, T4 and BMP4 overexpression in hepatocytes can upregulate GPX4 expression, thereby inhibiting ferroptosis, reducing hepatic oxidative stress and lipid peroxidation, and providing protection against NAFLD/NASH [200, 201]

Diabetologia 64 , 288303 (2021)

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