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Because this format has become so familiar within the skincare industry, consumers instinctively understand how to use it

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The expression levels of cross-linking enzymes and structural proteins produced by cellssuch as keratin laminin, filaggrin (FLG), transglutaminase-1, and keratin filamentthat are related to skin barrier function are downregulated under the action of ROS, thereby impairing skin barrier function ( FIGURE 5 4 Therapeutic strategies based on ROS regulation With the deepening understanding of the role of ROS in skin diseases, various therapeutic strategies targeting ROS regulation have been developed

Elsevier, Amsterdam, pp 375394 Hum DW, Bell AW, Rozen R, MacKenzie RE (1988) Primary structure of a human trifunctional enzyme