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Here are some ways your doctor can help: Adjusting Your Treatment Plan: If you experience significant skin sensitivity, your doctor might adjust your dosage or recommend a different medication

Metformin, the current first-line treatment in T2DM, has an unclear antidepressant effect [166] despite identified direct mechanisms and pleiotropic effects, including inhibition of angiotensin II and NF-B factor, normalization of gut microbiota, and intestinal permeabilization, and in vivo experimental data [167] supporting its potential benefits

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