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This benefit is central to studies focused on type 2 diabetes mechanisms, insulin sensitivity, and metabolic syndrome

Resmetirom (MGL-3196) addresses this issue by selectively activating THR- with a 28-fold affinity compared to THR- [16]

Despite the very low absolute risk for ischemic optic neuropathy, the rapidly expanding use of GLP-1 receptor agonists in patients with and without type 2 diabetes increases the clinical and public health importance of any potential association, conclude the authors