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To elucidate the molecular underpinnings of BBS-associated hyperphagia and weight gain, we performed bulk RNA-Seq on the hypothalamus of 5-week-old (pre-obesity) and 12-week-old (post-obesity) Bbs5 / mice

Data from a review of patient experiences and surveys involving more than 2200 patients with B12 deficiency in the UK indicate that many patients have concerns related to healthcare quality, safety, and treatment, with nearly two-thirds of respondents reporting that their treatment is insufficient to manage symptoms

Intracellular ROS levels depend on the balance between ROS generation and clearance, and are also manipulated by antioxidant defense mechanisms [6]

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