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Additionally, we analyzed postmortem human brain tissue with histopathologically confirmed AD or progressive supranuclear palsy (PSP), an age-associated tauopathy that clinically manifests as parkinsonism with additional motor abnormalities and cognitive dysfunction, and is neuropathologically defined by NFTs, gliosis and neurodegeneration (104)
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Leaky gut syndrome is now recognized for its role in numerous systemic diseases, including digestive diseases [245], cardiovascular diseases [246], Alzheimers disease, depression, Parkinsons disease [247,248], celiac disease [249], liver diseases [250] and renal diseases [251], metabolic syndrome [251], type 1 diabetes mellitus [252,253], and cancer [254,255]