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Publications from PubMed and Web of Science that met the selection criteria but lacked corresponding registry numbers were also retained to ensure a comprehensive overview of DHT applications in rare disease trials

Retrospective case series of paediatric patients referred to national poisons centres also report a lower rate of liver injury and hepatotoxicity in children compared with adults following single acute overdose [52,53,54,55]

Such reductions in blood pressure seem comparable to those reported with currently used classes of blood pressure-lowering medications (average reduction, -9.1 mm Hg for SBP and -5.5 mm Hg for DBP) (108)

Glutathione therapy is not automatic for every patient