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GLP-1R belongs to the class B family of G-protein-coupled receptors (GPCRs), which utilize a distinct peptide-binding mechanism compared to small-molecule GPCRs

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For example, in both neurodegenerative diseases like Alzheimer's and Parkinson's, the presence of fewer bacteria generating SCFA and the increased density of proinflammatory microbes lead to neuroinflammation and cognitive decline

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