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However, the efficacy of folate and B12 interventionsmay vary across individuals due to genetic polymorphisms, such as MTHFR variantshighlighting the importance of incorporating genomic profiling into personalized supplementation strategies

Rivinius, C

While there are a plethora of factors that come into play in losing weight (sleep, activity, medications, health conditions...), experts tend to agree that on the surface, a calorie deficit is one of the simplest and most effective strategies for weight loss

In SURMOUNT-4, adults who had lost an average of 20.9% on Mounjaro then switched to placebo regained 14% of their starting weight over the following year, retaining only about a third of the weight loss theyd initially achieved