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13a, Supplementary Table 9), suggesting that the distinct rotamer orientation of H296 ECL2 in Cagri-bound CTR (to accommodate the Glu linker) and/or the observed more open ECL3 conformation induced by the lipidated peptide may facilitate or stabilize an active CTR conformation (Supplementary Fig
Nature Reviews Disease Primers
In some embodiments, the antioxidant or anti-apoptotic agent protects against chemotherapy-induced ototoxicity
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