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Cell and Tissue Research 2019 Gwyer, Wragg & Wilson Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing A literature review surveying preclinical, in-vitro and animal-model studies of the pentadecapeptide and its reported interactions with soft-tissue and tendon-derived cells
It does both simultaneously through overlapping signaling mechanisms
It binds actin to influence cell motility and shape, promotes chemotaxis driving cell migration, enhances angiogenesis via cell surface ATP synthase interaction, and reduces inflammation through microRNA-146a upregulation
This is a reasonable position, and it is one of the arguments the July panel will need to weigh carefully against the absence of rigorous human trial data
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