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TdGSH totally blocked LOsG-induced -cell dedifferentiation and prevented Neurog3 expression and relocation of nuclear Pdx1 immunoreactivities (Fig

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This reduction in calorie intake, and subsequent weight loss, is believed to be caused by a decrease in appetite and cravings and a reduction in cravings for high-fat foods

Given that fluoropyrimidine-based therapy will remain a major treatment modality for patients with advanced CRC for the foreseeable future, the need for better, more effective chemotherapy combinations in biologically selected populations to overcome drug resistance is an urgent, unmet need for patients with CRC worldwide