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These results furthermore correlated with the reduction of CRP levels, which may suggest that anti-inflammatory action may be an important mechanism of the antidepressant effect of incretin-based drugs [121]

To date, the presence of GLP-1R in the renal vasculature has been confirmed but not in the tubules ( Oxidative Stress/Inflammation GLP-1RAs have been shown to prevent renal oxidative stress by inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase through the activation of PKA and the production of cyclic adenosine monophosphate (cAMP)

In conclusion, GLP-1 receptor agonists show potential in heart failure management through their multiple mechanisms of action, including direct cardioprotective effects, vasodilation, natriuresis, and glucose and weight control

DOI.org (Crossref) , Chedid, V., et al