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After consideration of the public comments we received, we are finalizing our proposal without modification to discontinue the low wage index hospital policy under the OPPS and use the FY 2026 IPPS post-reclassified wage index for urban and rural areas as finalized in the FY 2026 IPPS final rule as the wage index for the OPPS

At present, natalizumab, a humanized monoclonal antibody against the cell adhesion molecule 4-integrin, is advantageously used in the treatment of multiple sclerosis and Crohn's disease (24)

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