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Each of these receptors, when activated, triggers distinct downstream cellular responses related to insulin secretion, glucose metabolism, appetite regulation, and energy homeostasis

Has no effect on insulin or blood sugar

On one side, there are brand-name medications like Wegovy, Ozempic, Mounjaro, and Zepbound manufactured by Novo Nordisk and Eli Lilly, FDA-approved, and widely advertised

Accordingly, and in line with currently ongoing trials in HFpEF (ClinicalTrials.gov IDs NCT04916470 and NCT04788511), it may be relevant to consider obesity-related HFpEF as a specific (sub)phenotype, whether coexisting with type 2 diabetes or not