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Proc Natl Acad Sci USA 81:50075011 Migoya E, Miller J, Luo W-L et al (2010) Sitagliptin and metformin increase active GLP-1 by complementary mechanisms in treatment-nave patients with type 2 diabetes

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These results indicate that subchronic ISF, possibly via periodical gastrointestinal distension, ameliorates arrhythmic overeating and obesity via GLP-1 release and activation of capsaicin-sensitive sensory nerves including vagal afferents

And even when they do work, some patients struggle with side effects, fragmented care pathways and a lack of a clear and sustainable long-term end game