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As the focus was on establishing the acute direct effects of liraglutide, and not primarily those resulting from liraglutide-induced weight loss, participants were instructed not to change their diet, exercise program or daily routines during the trial to maintain their pre-trial body weight, and a wash-out period of 68 weeks was included between the two trial periods to avoid any metabolic carry-over effects of a body weight loss
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The formation of DON-GSH conjugates was also observed
Safety, Monitoring, and Eligibility Considerations Orderly Meds Review includes built-in safety screens for contraindications: personal or family history of medullary thyroid cancer, multiple endocrine neoplasia type 2, acute pancreatitis, severe renal impairment, and active diabetic retinopathy progression
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