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Activation (weeks 12): begin at the documented once-daily 330 mcg dose to establish tolerance and observe fluid-balance and injection-site response before committing to a full cycle

Cardiovascular Protection: Heart Health Benefits Beyond Weight Loss The SUSTAIN-6 trial, a landmark cardiovascular outcomes study, showed that semaglutide reduced the risk of major adverse cardiac eventsincluding heart attack, stroke, and cardiovascular deathby 26% compared to placebo in people with type 2 diabetes

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