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Clinical studies, including the STEP trial extensions, have demonstrated that many patients experience gradual weight increase after stopping treatment

Svegliati-Baroni G, Saccomanno S, Rychlicki C, Agostinelli L, De Minicis S, Candelaresi C, Faraci G, Pacetti D, Vivarelli M, Nicolini D, Garelli P, Casini A, Manco M, Mingrone G, Risaliti A, Frega GN, Benedetti A, Gastaldelli A

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A large observational study published in mid-2025 reported that diabetic patients using GLP-1 drugs experienced a two- to threefold increased risk of developing nAMD compared to non-users