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doi: 10.1016/j.bbrc.2016.10.099 174 GrahamDG

Mechanistically, CRC cells with high levels of dual specificity phosphatase 18 (DUSP18) stabilize the transcription factor upstream stimulatory factor 1 (USF1), which upregulates SREBF2, thereby increasing lanosterol biosynthesis (a substrate of CYP51A1) and its release into the TME

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