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The psychological impact of the COVID-19 pandemic, including fear of illness and disruptions to daily life, may contribute to disorders such as PTSD, anxiety, and depression (75, 76) ( Figure 2 )

Although the existence of mtNOS has been described in mitochondrial fractions from different organs, recent evidence in rat liver mitochondria has questioned the existence of mtNOS, minimizing the contribution of in situ NO generation within mitochondrial to the formation of peroxynitrite (Venkatakrishnan et al., 2009)

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This team-based approach is common in integrated injury care and improves outcomes, compliance, and patient satisfaction