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Lipid peroxidation decreased with WCM inoculated combinations

The barrier function is established by the lack of fenestrae in the vessels, the tight junctions connecting the endothelial cells, which prevent the paracellular route for external agents, and the low level of transcytotic vesicles (Rodrigues and Granger, 2015)

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Translating these in vitro findings to an in vivo model, naturally aged male mice from 20-24 months old were treated with FOXO4-DRI