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While not a primary outcome, the safety data revealed: Reduced alcohol consumption: Participants spontaneously decreased drinking, potentially due to reduced reward signaling GI side effects when drinking: Higher rates of nausea and vomiting in participants who drank alcohol compared to those who abstained No increase in severe adverse events: No clustering of liver injury or other serious alcohol-related complications These werent controlled alcohol studies, but the safety surveillance data suggests the combination isnt acutely dangerous for most people, though it does increase certain side effects