They highlight that inadvertent intravascular injection, high cumulative dosing, and patient factors (extremes of age, cardiac, hepatic, or renal disease, pregnancy) are major contributors, and that bupivacaine carries the greatest cardiotoxic risk
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Subsequent multiple linear regression analysis, using muscle mass loss as the dependent variable and Semaglutide dosage, baseline ASMI, handgrip strength, and gait speed as independent variables, confirmed independent associations for semaglutide dosage, baseline ASMI, and gait speed, whereas handgrip strength lost statistical significance
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